Evaluating hypoxia alleviation through induced downwelling

Preliminary Draft (Please do not cite) Evaluating Poverty Alleviation

Flaxseed Can Reduce Hypoxia-Induced Damages in Rat Testes

Introduction: Hypoxia is a common leading cause of detrimental effect on structure and function of tissue during increase in the production of reactive oxygen species that are generated during the re-oxygenation phase of intermittent continuous hypobaric hypoxia and contribute to physiological responses. This study was carried out to evaluate the effects of flaxseed (Fx) in reducing the inciden...

E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.

E2F6, a potent transcriptional repressor, plays important roles in cell cycle regulation. However, roles of E2F6 in hypoxia-induced apoptosis are unknown. Here, we demonstrated biological functions of E2F6 in hypoxia-induced apoptosis and regulatory pathways. During hypoxia (CoCl(2), 800 microM)-induced human embryonic kidney 293 cell apoptosis, E2F6 expression was down-regulated with concurren...

Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation.

Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has been found to afford neuroprotective effects against neuroinflammation in the brain. Activated microglia can secrete various pro-inflammatory cytokines and neurotoxic mediators, which may contribute to hypoxic brain injuries. The aim of this study is to investigate the potential role of resveratrol in attenuating hypox...

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

N-methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer's disease (AD) and Parkinson's disease. However, no effective treatments for the same have been developed so far. Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many c...